All Huntington's Disease Trials

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Showing 3 of 103 active studiesUpdated 22 Aug 2026

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

Hoffmann-La Roche

Phase 1/2 study testing SPK-10001 in Huntington's disease.

RecruitingPhase 1 / Phase 2GeneticClinicalTrials.govTreatment trial

Recruiting in: Boston, Cincinnati, Columbus +2 more, United States

View on ClinicalTrials.gov

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease

POINT-HD · Hoffmann-La Roche

Phase 1 study testing RG6496 to assess its safety and tolerability in people with Huntington's disease.

Active, not recruitingPhase 1DrugClinicalTrials.govTreatment trial

EU sites are temporarily halted (CTIS (EU))

Recruiting in: Cambridge, Christchurch, Ciudad Autonoma Bs As +4 more (Argentina, Australia, Canada +8 more)

View on ClinicalTrials.gov

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

Hoffmann-La Roche

Phase 2 study testing tominersen in Huntington's disease.

Active, not recruitingPhase 2DrugClinicalTrials.govTreatment trial

Recruiting in: Aachen, Amherst, Angers +66 more (Argentina, Australia, Austria +12 more)

View on ClinicalTrials.gov