All Huntington's Disease Trials

A feasibility study of real-time displays of brain activity as a treatment for symptoms in Huntington's disease

HD-BrainTrain · University College London Hospitals NHS Foundation Trust

Study testing an investigational treatment in Huntington's disease.

A feasibility trial to examine the use of guided self-help for Huntington’s disease gene expansion carriers with anxiety

GUIDE-HD v.1.0 · Leicestershire Partnership NHS Trust

Study testing an investigational treatment in Huntington's disease.

A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease

Sarepta Therapeutics, Inc.

Phase 1 study testing SRP-1005 in Huntington's disease.

A multicentre, multinational prospective observational imaging biomarker study in early stage Huntington’s disease (HD) patients to assess imaging techniques and parameters able to support efficacy studies with SEN0014196 in HD patients during Phase II and III studies

SEN0014196 · Siena Biotech (Italy)

Phase 1/2 study testing an investigational treatment in Huntington's disease.

A multicentre, multinational, double blind, randomised, parallel group, placebo-controlled study of ethyl-eicosapentaenoate (EPA) in patients with Huntington's disease (HD)

Laxdale Ltd (UK)

Study testing an investigational treatment in Huntington's disease.

A Phase 2a, Randomized, Placebo-controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of PTC518 in Subjects with Huntington’s Disease

PTC518-CNS-002-HD · PTC Therapeutics Inc.

Phase 2 study testing PTC518 in Huntington's disease.

A Phase I Clinical Study of ER2001 Injection for the Treatment of Early Manifest Huntington's Disease.

ExoRNA Bioscience

Phase 1/2 study testing ER2001 in Huntington's disease.

A Phase I Randomised, Double Blind, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics

Related trial records · Skyhawk Therapeutics, Inc.

Phase 1 study testing an investigational treatment in healthy participants.

A phase IIa, open label, single centre study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of orally dosed MBF-015 in Huntington's disease patients

MBF-015CT-02 · Medibiofarma S.L.

Phase 2 study testing MBF-015 in Huntington's disease.

A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers

NAC-preHD · Western Sydney Local Health District

Phase 2 study testing an investigational treatment in Huntington's disease.

A randomised, double-blind, placebo-controlled, cross-over pilot study using nabilone for symptomatic relief in patients with Huntington's disease

Birmingham and Solihull Mental Health Trust (UK)

Study testing an investigational treatment in Huntington's disease.

A Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease

Hoffmann-La Roche

Phase 1/2 study testing SPK-10001 in Huntington's disease.

A randomized trial of varenicline (Champix) for the treatment of cognitive and affective symptoms in Huntington's Disease

VCAS-HD · University of Auckland

Phase 2 study testing varenicline in Huntington's disease.

A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of Intrathecal Administration of RO7234292 (RG6042) in Patients with Manifest Huntington's Disease

Phase 5 study testing RG6042 in Huntington's disease.

A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD

VO659-CT01 · Vico Therapeutics B. V.

Phase 1/2 study testing VO659 to assess its safety and tolerability in people with Huntington's disease.

A single site, open label, phase I study to assess the safety and feasibility of foetal cell transplants in the striatum of people with Huntington’s disease

TRIDENT · Cardiff University

Study testing an investigational treatment in Huntington's disease.

A study in healthy volunteers to investigate how the test medicine, zavacorilant, is taken up by the body when given in different dose levels, with food and without food

QSC301567 · Corcept Therapeutics (United States)

A study to assess the long-term safety of SAGE-718 in participants with Huntington’s disease

Sage Therapeutics (United States)

Phase 3 study testing SAGE-718 to assess its safety and tolerability in people with Huntington's disease.

A Study to Evaluate AB-1001 Striatal Administration in Adults With Early Manifest Huntington's Disease

AskBio France, SAS, a subsidiary of AskBio Inc.

Phase 1/2 study testing AB-1001 in Huntington's disease.

A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease

Alnylam Pharmaceuticals

Phase 1 study testing an investigational treatment in Huntington's disease.

A study to evaluate the effect of SAGE-718 on cognitive function in participants with Huntington's Disease

DIMENSION · Sage Therapeutics, Inc.

Phase 2 study testing SAGE-718 in Huntington's disease.

A study to evaluate the safety and efficacy of PTC518 in participants with Huntington's disease (HD)

PIVOT HD · PTC Therapeutics International Limited

Phase 2 study testing PTC518 to see whether it can slow the progression of Huntington's disease.

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease

POINT-HD · Hoffmann-La Roche

Phase 1 study testing RG6496 to assess its safety and tolerability in people with Huntington's disease.

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

INVEST-HD · Novartis Pharmaceuticals

Phase 3 study testing votoplam to assess its safety and tolerability in people with Huntington's disease.

A trial to look at how different doses of felodipine are tolerated in people with early-stage Huntington’s disease

FELL-HD · Cambridge Clinical Trials Unit

Phase 2 study testing felodipine to assess its safety and tolerability in people with Huntington's disease.

An Extension of SKY-0515 in Participants With Huntington's Disease

Skyhawk Therapeutics, Inc.

Phase 2/3 study testing SKY-0515 to see whether it can lower harmful huntingtin protein levels.

An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)

Novartis Pharmaceuticals

Phase 2 study testing votoplam in Huntington's disease.

An observational study providing new insights into lifestyle and genetic risk factors in Huntington’s disease

DOMINO-HD · Cardiff University

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

Anti-depressants for depression in Huntington's disease

DEVISE-HD · Cardiff University

Phase 4 study testing an investigational treatment in Huntington's disease.

Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease

MAMOC-MH · University Hospital, Angers

Biology-Driven Cognitive Profiling in Huntington's Disease

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Observational study following people affected by Huntington's disease — no treatment is being tested.

Brain Bites Huntington's Disease: A Mediterranean meal box for families

Brain Bites HD · Centre for Precision Health (Edith Cowan University)

Cognitive Assessment Tools for Huntington's Disease.

CAT-HD · Ohio State University

Observational study following people affected by Huntington's disease — no treatment is being tested.

Community-based Exercise Therapies for Huntington's Disease

COMMET-HD · Cardiff University (UK)

Phase 1 study testing an exercise programme in Huntington's disease.

Comparison Between [11C]UCB-J and [18F]SynVest-1 PET in HD.

Universitaire Ziekenhuizen KU Leuven

Observational study following people affected by Huntington's disease — no treatment is being tested.

Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients

CARE-MH · University Hospital, Angers

Study testing a training programme in Huntington's disease.

Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases

Hadassah Medical Organization

Observational study following people affected by Huntington's disease — no treatment is being tested.

Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

DANNIgene · Assistance Publique - Hôpitaux de Paris

Observational study following people affected by Huntington's disease — no treatment is being tested.

Digital Measures for Clinical Trial Endpoints in Huntington's Disease

MEND-HD · University of Rochester

Observational study following people affected by Huntington's disease — no treatment is being tested.

Early Biomarkers in Premanifest Huntington's Disease Gene Carriers: a Pilot Study

BIO-MH · University Hospital, Grenoble

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

CHDI Foundation, Inc.

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

Evaluation of Three Tests to Assess Social Cognition in Huntington Disease

Region Skane

Observational study following people affected by Huntington's disease — no treatment is being tested.

ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders

InSightec

Study testing a device in Huntington's disease.

Exercise rehabilitation trial in Huntington'’s disease

ExeRT-HD · Cardiff University (UK)

Study testing an exercise programme in Huntington's disease.

Extracellular Vesicles for HD

University of Central Florida

Observational study following people affected by Huntington's disease — no treatment is being tested.

Feasibility and Acceptability of an LLM-based Chatbot for Family Caregivers: Evaluation Study

University of Michigan

Observational study following people affected by Huntington's disease — no treatment is being tested.

Feasibility study of HD-DRUM - a novel drumming training app for people with Huntington's disease

HD-DRUM · Cardiff University

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

xCures

Observational study following people affected by Huntington's disease — no treatment is being tested.

Gait Analysis in Neurological Disease

Beth Israel Deaconess Medical Center

Observational study following people affected by Huntington's disease — no treatment is being tested.

Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Acti-Adult · Centre Hospitalier Universitaire de Liege

Observational study following people affected by Huntington's disease — no treatment is being tested.

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo in Participants With Prodromal and Early Manifest Huntington's Disease

Hoffmann-La Roche

Phase 2 study testing tominersen in Huntington's disease.

Gut Microbiomes in HD

University of Central Florida

Observational study following people affected by Huntington's disease — no treatment is being tested.

HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

HDClarity · University College, London

Observational study following people affected by Huntington's disease — no treatment is being tested.

Hinting Task for Huntington's Disease

HT-HD · University Medical Center Groningen

Observational study following people affected by Huntington's disease — no treatment is being tested.

Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease

The University of Texas Health Science Center at San Antonio

Study testing a device in Huntington's disease.

Home-based Transcranial Direct Current Stimulation Open Trial for Behavioral and Cognitive Symptoms in Huntington's Disease

The University of Texas Health Science Center, Houston

Study testing a device in Huntington's disease.

Huntington’s disease (HD) is an autosomal dominant neurodegenerative illness characterized by disorders of movement, cognition, behavior, and functional capacit

North Metropolitan Area Health Service

Study testing an investigational treatment in Huntington's disease.

Huntington's Disease and Pain

HD-P1 · Leiden University Medical Center

Observational study following people affected by Huntington's disease — no treatment is being tested.

Huntington's Disease Biobank: Advancing Remote Monitoring and Deep Phenotyping

Stanford University

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009

iMagemHTT-009 · CHDI Foundation, Inc.

Early Phase 1 study testing a procedure in Huntington's disease.

IMarkHD: in Vivo Longitudinal Imaging of HD Pathology

King's College London

Observational study following people affected by Huntington's disease — no treatment is being tested.

Immune-responsive cells of the brain – namely microglia and astrocytes – activate in response to brain injury or pathogens. This activation leads to a local neu

Monash University

Impact of Deutetrabenazine on Functional Speech and Gait Dynamics in Huntington Disease

Vanderbilt University Medical Center

Phase 2/3 study testing deutetrabenazine in Huntington's disease.

Improving opportunities for engagement for hospital inpatients with Huntington's Disease

Related trial records · Calvary Health Care Bethlehem

Innovative Imaging and Cognitive BIOmarkers to Predict Huntington's Disease Progression

I2BIO-HD · Assistance Publique - Hôpitaux de Paris

Inspiratory muscle training in people with Huntington's disease

FIMTHD · Cardiff University (UK)

Study testing a training programme in Huntington's disease.

Long Term Follow-up Grafted Huntington's Disease Patients

Post-MIGHD · Assistance Publique - Hôpitaux de Paris

Study testing an investigational treatment in Huntington's disease.

Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada

Neurocrine Biosciences

Phase 3 study testing valbenazine to assess its safety and tolerability in people with Huntington's disease.

Longitudinal Assessment of Brain Structure and Function in Juvenile-onset Huntington's Disease

University of Iowa

Observational study following people affected by Huntington's disease — no treatment is being tested.

Longitudinal Endpoint Assessment of Disease Burden in HD

LEAD-HD · Huntington Study Group

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

Longitudinal SV2A PET and MRI in Premanifest HD

Universitaire Ziekenhuizen KU Leuven

Observational study following people affected by Huntington's disease — no treatment is being tested.

Mass Balance Study of [14C] LPM3770164 in Healthy Participants

Luye Pharma Group Ltd.

Phase 1 study investigating how the body processes an investigational treatment in healthy participants.

Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3)

University of Virginia

Study testing a behavioural intervention in Huntington's disease.

Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease

BioDigit HD-02 · BioSensics

Observational study following people affected by Huntington's disease — no treatment is being tested.

Neurobiological Predictors of Huntington's Disease (PREDICT-HD)

PREDICT-HD · Jordan Schultz

Observational study following people affected by Huntington's disease — no treatment is being tested.

NYSCF Scientific Discovery Biobank

New York Stem Cell Foundation Research Institute

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease

First Affiliated Hospital of Fujian Medical University

Study testing a device in Huntington's disease.

Pridopidine Phase 3 Study in Huntington's Disease

PRECISE-HD · Prilenia

Phase 3 study testing pridopidine to see whether it can slow the progression of Huntington's disease.

Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers

PICSI-M · University of Washington

Study testing a behavioural intervention in Huntington's disease.

Randomised, double-blind, placebo-controlled study to evaluate the effect of metformin, an AMPK activator, on cognitive measures of progression in Huntington's disease patients.

TEMET-HD · IIS La Fe

Phase 3 study testing an investigational treatment in Huntington's disease.

Respiratory function in people with Huntington's disease

Cardiff University (UK)

Observational study following people affected by Huntington's disease — no treatment is being tested.

Retinal Imaging in Neurodegenerative Disease

Duke University

Observational study following people affected by Huntington's disease — no treatment is being tested.

Safety and Efficacy of AMT-130 in European Adults With Early Manifest Huntington's Disease

UniQure Biopharma B.V.

Phase 1/2 study testing AMT-130 in Huntington's disease.

Safety and feasibility of neural transplantation in early to moderate Huntington's disease in the UK

Medical Research Council (UK)

Observational study following people affected by Huntington's disease — no treatment is being tested.

Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease

UniQure Biopharma B.V.

Phase 1/2 study testing AMT-130 in Huntington's disease.

Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

REGEN4HD · Leslie Thompson

Phase 1/2 study testing an investigational treatment to assess its safety and tolerability in people with Huntington's disease.

ScATtEred Rare Disease Biobanks: a Model of Sample/Data Collection With susTainablE and Shared Criteria

SATELLITES · IRCCS Policlinico S. Donato

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.

Social Cognition Training in Individuals With Huntington's Disease

Rush University Medical Center

Study testing a training programme in Huntington's disease.

Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study

DEGERWD · Kuopio University Hospital

Observational study following people affected by Huntington's disease — no treatment is being tested.

Study Aims This study aims to assess feasibility, therapeutic utility and cost effectiveness of multidisciplinary therapy coaching compared to lifestyle guidanc

Perpetual Limited

Study testing a behavioural intervention in Huntington's disease.

Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington's Disease

LCR-MH · University Hospital, Montpellier

Study testing a procedure in Huntington's disease.

Study of SKY-0515 for Safety, Efficacy, and Pharmacodynamics in Participants With Huntington's Disease

Falcon-HD · Skyhawk Therapeutics, Inc.

Phase 2/3 study testing SKY-0515 to see whether it can lower harmful huntingtin protein levels.

Study to compare the pharmacokinetics, safety and tolerability of the pediatric and adult branaplam formulation in healthy adults and the effect of food on the latter

QSC205070 · Novartis (Switzerland)

Study testing branaplam in healthy participants.

Study to Evaluate Music Therapy on Irritability and Impulsivity in Patients With Huntington's Disease (MUSIC-HD)

MUSIC-HD · Poitiers University Hospital

Study testing an investigational treatment in Huntington's disease.

Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease

FALCON-HD · Skyhawk Therapeutics, Inc.

Phase 2/3 study testing SKY-0515 to see whether it can lower harmful huntingtin protein levels.

Supporting activity engagement in people with Huntington's disease

ENGAGE-HD · Cardiff University (UK)

Task-related TRAINing in Huntingtons Disease

TRAIN · Cardiff University (UK)

Study testing a training programme in Huntington's disease.

The effects of environmental enrichment on clinical measures of disease progression and quality of life for patients with Huntington's disease.

HEROs · Edith Cowan University

Study testing a behavioural intervention in Huntington's disease.

The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease

NAD-HD · Oslo University Hospital

Phase 2 study testing a dietary supplement to see whether it can slow the progression of Huntington's disease.

This is a study of safety and tolerability of a drug called SLS-005 in adults, aged 18 to 75 years with selected neurodegenerative diseases [up to 4 patients wi

Avance Clinical

Study testing SLS-005 to assess its safety and tolerability in people with Huntington's disease.

Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD)

Neuromed IRCCS

Study testing a device in Huntington's disease.

Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease

HUNTIAM · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Phase 2 study testing thiamine to assess its safety and tolerability in people with Huntington's disease.

University of Central Florida CereBank

University of Central Florida

Registry study collecting information from people affected by Huntington's disease — no treatment is being tested.